Publications

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Mukhi D, Li L, Liu H, Doke T, Kolligundla LP,  Ha E, Kloetzer K, Abedini A, Mukherjee S, Wu J, Dhillon P, Hu H, Guan  D, Funai K, Uehara K, Titchenell PM, Baur JA, Wellen KE, Susztak K.  ACSS2 gene variants determine kidney disease risk by controlling de novo  lipogenesis in kidney tubules. J Clin Invest. 2023 Dec  5;134(4):e172963. doi: 10.1172/JCI172963. PMID: 38051585; PMCID:  PMC10866669.

Zhu K, Celwyn IJ, Guan D, Xiao Y, Wang X, Hu  W, Jiang C, Cheng L, Casellas R, Lazar MA. An intrinsically disordered  region controlling condensation of a circadian clock component and  rhythmic transcription in the liver. Mol Cell. 2023 Oct  5;83(19):3457-3469.e7. doi: 10.1016/j.molcel.2023.09.010. PMID:  37802023; PMCID: PMC10575687.

Guan D, Bae H, Zhou D, Chen Y, Jiang C, La  CM, Xiao Y, Zhu K, Hu W, Trinh TM, Liu P, Xiong Y, Cai B, Jang C, Lazar  MA. Hepatocyte SREBP signaling mediates clock communication within the  liver. J Clin Invest. 2023 Apr 17;133(8):e163018. doi:  10.1172/JCI163018. PMID: 37066875; PMCID: PMC10104893.

Cheng C, Zhang S, Guan D, Wang Y, Jyotsana N. Editorial: Tumor metabolism: From molecular mechanisms to clinical application. Front Cell Dev Biol. 2023 Feb 17;11:1158467. doi: 10.3389/fcell.2023.1158467. PMID: 36875758; PMCID: PMC9982143. 

 Xiao Y, Batmanov K, Hu W, Zhu K, Tom AY, Guan D, Jiang C, Cheng L, McCright SJ, Yang EC, Lanza MR, Liu Y, Hill DA, Lazar MA. Hepatocytes demarcated by EphB2 contribute to the progression of nonalcoholic steatohepatitis. Sci Transl Med. 2023 Feb 8;15(682):eadc9653. doi: 10.1126/scitranslmed.adc9653. Epub 2023 Feb 8. PMID: 36753562. 

Jiang C, Liu P, La C, Guan D. In silico integrative analysis of multi-omics reveals regulatory layers for diurnal gene expression in mouse liver. Front. Endocrinol., 22 July 2022

Sec. Diabetes: Molecular Mechanisms doi: 10.3389/fendo.2022.955070

Guan D, Lazar MA. Circadian Regulation of Gene Expression and Metabolism in the Liver. Semin Liver Dis. 2022 May;42(2):113-121. doi: 10.1055/a-1792-4240. Epub 2022 Mar 9. Review. PubMed PMID: 35263797. 

Hu W, Jiang C, Kim M, Xiao Y, Richter HJ, Guan D, Zhu K, Krusen BM, Roberts AN, Miller J, Steger DJ, Lazar MA. Isoform-specific functions of PPARγ in gene regulation and metabolism. Genes Dev. 2022 Mar 1;36(5-6):300-312. doi: 10.1101/gad.349232.121. Epub 2022 Mar 10. PubMed PMID: 35273075; PubMed Central PMCID: PMC8973844. 

Hu W, Jiang C, Kim M, Yang W, Zhu K, Guan D, Lv W, Xiao Y, Wilson JR, Rader DJ, Pui CH, Relling MV, Lazar MA. Individual-specific functional epigenomics reveals genetic determinants of adverse metabolic effects of glucocorticoids. Cell Metab. 2021 Aug 3;33(8):1592-1609.e7. doi: 10.1016/j.cmet.2021.06.004. Epub 2021 Jul 6. PubMed PMID: 34233159; PubMed Central PMCID: PMC8340270 

Guan D, Lazar MA. Interconnections between circadian clocks and metabolism. J Clin Invest. 2021 Aug 2;131(15). doi: 10.1172/JCI148278. Review. PubMed PMID: 34338232; PubMed Central PMCID: PMC8321578. 

Fang B, Guan D, Lazar MA. Using GRO-Seq to Measure Circadian Transcription and Discover Circadian Enhancers. Methods Mol Biol. 2021;2130:127-148. doi: 10.1007/978-1-0716-0381-9_10. PubMed PMID: 33284441; PubMed Central PMCID: PMC8073214. 

Guan D, Xiong Y, Trinh TM, Xiao Y, Hu W, Jiang C, Dierickx P, Jang C, Rabinowitz JD, Lazar MA. The hepatocyte clock and feeding control chronophysiology of multiple liver cell types. Science. 2020 Sep 11;369(6509):1388-1394. doi: 10.1126/science.aba8984. Epub 2020 Jul 30. PubMed PMID: 32732282; PubMed Central PMCID: PMC7849028. 

Guan D, Lazar MA. Shining light on dark matter in the genome. Proc Natl Acad Sci U S A. 2019 Dec 10;116(50):24919-24921. doi: 10.1073/pnas.1918894116. Epub 2019 Nov 18. PubMed PMID: 31740615; PubMed Central PMCID: PMC6911184. 

Hu W, Jiang C, Guan D, Dierickx P, Zhang R, Moscati A, Nadkarni GN, Steger DJ, Loos RJF, Hu C, Jia W, Soccio RE, Lazar MA. Patient Adipose Stem Cell-Derived Adipocytes Reveal Genetic Variation that Predicts Antidiabetic Drug Response. Cell Stem Cell. 2019 Feb 7;24(2):299-308.e6. doi: 10.1016/j.stem.2018.11.018. Epub 2019 Jan 10. PubMed PMID: 30639037; PubMed Central PMCID: PMC6368460. 

Guan D, Xiong Y, Borck PC, Jang C, Doulias PT, Papazyan R, Fang B, Jiang C, Zhang Y, Briggs ER, Hu W, Steger D, Ischiropoulos H, Rabinowitz JD, Lazar MA. Diet-Induced Circadian Enhancer Remodeling Synchronizes Opposing Hepatic Lipid Metabolic Processes. Cell. 2018 Aug 9;174(4):831-842.e12. doi: 10.1016/j.cell.2018.06.031. Epub 2018 Jul 26. PubMed PMID: 30057115; PubMed Central PMCID: PMC6086765. 

Borck PC, Batista TM, Vettorazzi JF, Soares GM, Lubaczeuski C, Guan D, Boschero AC, Vieira E, Lazar MA, Carneiro EM. Nighttime light exposure enhances Rev-erbα-targeting microRNAs and contributes to hepatic steatosis. Metabolism. 2018 Aug;85:250-258. doi: 10.1016/j.metabol.2018.05.002. Epub 2018 May 8. PubMed PMID: 29751019; PubMed Central PMCID: PMC6145802. 

Zhang Y, Papazyan R, Damle M, Fang B, Jager J, Feng D, Peed LC, Guan D, Sun Z, Lazar MA. The hepatic circadian clock fine-tunes the lipogenic response to feeding through RORα/γ. Genes Dev. 2017 Jun 15;31(12):1202-1211. doi: 10.1101/gad.302323.117. Epub 2017 Jul 26. PubMed PMID: 28747429; PubMed Central PMCID: PMC5558923. 

Hsu KS, Zhao X, Cheng X, Guan D, Mahabeleshwar GH, Liu Y, Borden E, Jain MK, Kao HY. Dual regulation of Stat1 and Stat3 by the tumor suppressor protein PML contributes to interferon α-mediated inhibition of angiogenesis. J Biol Chem. 2017 Jun 16;292(24):10048-10060. doi: 10.1074/jbc.M116.771071. Epub 2017 Apr 21. PubMed PMID: 28432122; PubMed Central PMCID: PMC5473212. 

Zhang Y, Fang B, Damle M, Guan D, Li Z, Kim YH, Gannon M, Lazar MA. HNF6 and Rev-erbα integrate hepatic lipid metabolism by overlapping and distinct transcriptional mechanisms. Genes Dev. 2016 Jul 15;30(14):1636-44. doi: 10.1101/gad.281972.116. Epub 2016 Jul 21. PubMed PMID: 27445394; PubMed Central PMCID: PMC4973293. 

Hsu KS, Guan BJ, Cheng X, Guan D, Lam M, Hatzoglou M, Kao HY. Translational control of PML contributes to TNFα-induced apoptosis of MCF7 breast cancer cells and decreased angiogenesis in HUVECs. Cell Death Differ. 2016 Mar;23(3):469-83. doi: 10.1038/cdd.2015.114. Epub 2015 Sep 18. PubMed PMID: 26383972; PubMed Central PMCID: PMC5072441. 

Guan D, Kao HY. The function, regulation and therapeutic implications of the tumor suppressor protein, PML. Cell Biosci. 2015;5:60. doi: 10.1186/s13578-015-0051-9. eCollection 2015. Review. PubMed PMID: 26539288; PubMed Central PMCID: PMC4632682. 

Adorno-Cruz V, Kibria G, Liu X, Doherty M, Junk DJ, Guan D, Hubert C, Venere M, Mulkearns-Hubert E, Sinyuk M, Alvarado A, Caplan AI, Rich J, Gerson SL, Lathia J, Liu H. Cancer stem cells: targeting the roots of cancer, seeds of metastasis, and sources of therapy resistance. Cancer Res. 2015 Mar 15;75(6):924-9. doi: 10.1158/0008-5472.CAN-14-3225. Epub 2015 Jan 20. Review. PubMed PMID: 25604264; PubMed Central PMCID: PMC4359955. 

Guan D, Lim JH, Peng L, Liu Y, Lam M, Seto E, Kao HY. Deacetylation of the tumor suppressor protein PML regulates hydrogen peroxide-induced cell death. Cell Death Dis. 2014 Jul 17;5:e1340. doi: 10.1038/cddis.2014.185. PubMed PMID: 25032863; PubMed Central PMCID: PMC4123062. 

Guan D, Factor D, Liu Y, Wang Z, Kao HY. The epigenetic regulator UHRF1 promotes ubiquitination-mediated degradation of the tumor-suppressor protein promyelocytic leukemia protein. Oncogene. 2013 Aug 15;32(33):3819-28. doi: 10.1038/onc.2012.406. Epub 2012 Sep 3. PubMed PMID: 22945642; PubMed Central PMCID: PMC3578017. 

Khurana S, Chakraborty S, Zhao X, Liu Y, Guan D, Lam M, Huang W, Yang S, Kao HY. Identification of a novel LXXLL motif in α-actinin 4-spliced isoform that is critical for its interaction with estrogen receptor α and co-activators. J Biol Chem. 2012 Oct 12;287(42):35418-35429. doi: 10.1074/jbc.M112.401364. Epub 2012 Aug 20. PubMed PMID: 22908231; PubMed Central PMCID: PMC3471738. 

 Li G, Xu Y, Guan D, Liu Z, Liu DX. HSP70 protein promotes survival of C6 and U87 glioma cells by inhibition of ATF5 degradation. J Biol Chem. 2011 Jun 10;286(23):20251-9. doi: 10.1074/jbc.M110.211771. Epub 2011 Apr 25. PubMed PMID: 21521685; PubMed Central PMCID: PMC3121475. 

Yang M, Yu M, Guan D, Gu J, Cao X, Wang W, Zheng S, Xu Y, Shen Z, Liu X. ASK1-JNK signaling cascade mediates Ad-ST13-induced apoptosis in colorectal HCT116 cells. J Cell Biochem. 2010 Jun 1;110(3):581-8. doi: 10.1002/jcb.22551. PubMed PMID: 20512919. 

Xu YY, Guan DY, Yang M, Wang H, Shen ZH. All-trans-retinoic acid intensifies endoplasmic reticulum stress in N-acetylglucosaminyltransferase V repressed human hepatocarcinoma cells by perturbing homocysteine metabolism. J Cell Biochem. 2010 Feb 15;109(3):468-77. doi: 10.1002/jcb.22423. PubMed PMID: 19960509. 

Hao R, Bian Y, Li X, Gu D, Jiang P, Huang W. Screening for 3-deoxy-D-arabino-hepeulosonate-7-Phosphate Synthase (AroG) Mutants Resistant to Phenylalanine Feedback-inhibition by Using DNA Shuffling Method [. Journal of Fudan University (Natural Science). 2010; 3:005. 

Guan D, Xu Y, Yang M, Wang H, Wang X, Shen Z. N-acetyl cysteine and penicillamine induce apoptosis via the ER stress response-signaling pathway. Mol Carcinog. 2010 Jan;49(1):68-74. doi: 10.1002/mc.20578. PubMed PMID: 19722195. 

Guan D, Wang H, Li VE, Xu Y, Yang M, Shen Z. N-glycosylation of ATF6beta is essential for its proteolytic cleavage and transcriptional repressor function to ATF6alpha. J Cell Biochem. 2009 Nov 1;108(4):825-31. doi: 10.1002/jcb.22310. PubMed PMID: 19693772. 

Wang XM, Li J, Feng XC, Wang Q, Guan DY, Shen ZH. Involvement of the role of Chk1 in lithium-induced G2/M phase cell cycle arrest in hepatocellular carcinoma cells. J Cell Biochem. 2008 Jul 1;104(4):1181-91. doi: 10.1002/jcb.21693. PubMed PMID: 18247328. 

Huang Q, Wang Z, Ruan Z, Guan D, Yang J. Study on Decoloration by Cold Plasmas Using Dielectric Barrier Discharge. High Voltage Engineering. 2007; 2:046. 

Guan D. Research on novel sterilization device for non-thermal plasma with liquid-film flow. Journal of Fuzhou University (Natural Science Edition). 2006; 1:036.